John Isner defeated Florian Mayer 7-6 7-6 in the Rome Masters round of 32 on clay. John Isner extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2013-08-11 | Cincinnati Masters | R64 | hard | John Isner | 6-3 6-4 |
| 2012-03-21 | Miami Masters | R32 | hard | Florian Mayer | 6-4 6-2 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 69). ATP, WTA & Challenger.