John Isner defeated Florian Mayer 6-3 6-4 in the Cincinnati Masters round of 64 on hard. The upset overturned the form book — Florian Mayer came in defending last year's round of 32. John Isner extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2017-05-15 | Rome Masters | R32 | clay | John Isner | 7-6(4) 7-6(4) |
| 2012-03-21 | Miami Masters | R32 | hard | Florian Mayer | 6-4 6-2 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 199). ATP, WTA & Challenger.