Florian Mayer defeated John Isner 6-4 6-2 in the Miami Masters round of 32 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 2–0, defending last year's round of 16. Florian Mayer claimed a first win over John Isner in three meetings, narrowing the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2017-05-15 | Rome Masters | R32 | clay | John Isner | 7-6(4) 7-6(4) |
| 2013-08-11 | Cincinnati Masters | R64 | hard | John Isner | 6-3 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.