John Isner defeated Jurgen Melzer 6-3 6-4 in the Indian Wells Masters round of 64 on hard. The upset overturned the form book — Jurgen Melzer came in leading the head-to-head 3–1. John Isner narrowed the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2014-05-11 | Rome Masters | R64 | clay | Jurgen Melzer | 7-6(7) 6-3 |
| 2012-08-19 | Winston-Salem | R16 | hard | John Isner | 6-4 6-3 |
| 2012-02-20 | Memphis | QF | hard | Jurgen Melzer | 6-3 7-6(6) |
| 2008-02-25 | Memphis | R32 | hard | Jurgen Melzer | 6-7(8) 6-3 7-6(4) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 101). ATP, WTA & Challenger.