Jurgen Melzer defeated John Isner 7-6 6-3 in the Rome Masters round of 64 on clay. Jurgen Melzer extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2015-03-12 | Indian Wells Masters | R64 | hard | John Isner | 6-3 6-4 |
| 2012-08-19 | Winston-Salem | R16 | hard | John Isner | 6-4 6-3 |
| 2012-02-20 | Memphis | QF | hard | Jurgen Melzer | 6-3 7-6(6) |
| 2008-02-25 | Memphis | R32 | hard | Jurgen Melzer | 6-7(8) 6-3 7-6(4) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (137 vs 200). ATP, WTA & Challenger.