John Isner defeated Guillermo Garcia Lopez 6-3 6-4 6-4 in the US Open round of 128 on hard. The result followed the form book — John Isner came in leading the head-to-head 2–1, defending last year's quarter-final. John Isner extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2013-05-05 | Madrid Masters | R64 | clay | John Isner | 7-5 7-6(8) |
| 2010-01-11 | Auckland | R32 | hard | John Isner | 4-6 7-6(3) 6-2 |
| 2008-02-18 | San Jose | QF | hard | Guillermo Garcia Lopez | 7-6(4) 6-7(1) 7-6(11) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (164 vs 73). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About