Guillermo Garcia Lopez defeated John Isner 7-6 6-7 7-6 in the San Jose quarter-final on hard. The upset overturned the form book — John Isner came in leading the head-to-head 3–0. Guillermo Garcia Lopez claimed a first win over John Isner in four meetings, narrowing the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-08-26 | US Open | R128 | hard | John Isner | 6-3 6-4 6-4 |
| 2013-05-05 | Madrid Masters | R64 | clay | John Isner | 7-5 7-6(8) |
| 2010-01-11 | Auckland | R32 | hard | John Isner | 4-6 7-6(3) 6-2 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About