Cristian Garin defeated John Isner 6-3 6-4 in the Canada Masters round of 32 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 2–1, defending last year's round of 16. Cristian Garin narrowed the head-to-head to 2–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-04-04 | Houston | SF | clay | John Isner | 4-6 6-3 6-4 |
| 2021-08-09 | Canada Masters | R32 | hard | John Isner | 4-6 6-3 6-4 |
| 2019-10-28 | Paris Masters | R32 | hard | Cristian Garin | 7-6(5) 7-6(4) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 164). ATP, WTA & Challenger.