
Nick Kyrgios defeated Daniil Medvedev 6-3 3-6 6-3 in the Rome Masters round of 64 on clay. The upset overturned the form book — Daniil Medvedev came in ranked #8, defending last year's round of 64. Nick Kyrgios extended the head-to-head to 4–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-08-29 | US Open | R16 | hard | Nick Kyrgios | 7-6(11) 3-6 6-3 6-2 |
| 2022-08-08 | Canada Masters | R32 | hard | Nick Kyrgios | 6-7(2) 6-4 6-2 |
| 2022-01-17 | Australian Open | R64 | hard | Daniil Medvedev | 7-6(1) 6-4 4-6 6-2 |
| 2019-07-29 | Washington | F | hard | Nick Kyrgios | 7-6(6) 7-6(4) |
Averages from each player's recent completed matches (20 vs 19). ATP, WTA & Challenger.