Daniil Medvedev defeated Kei Nishikori 6-2 6-4 in the Tokyo final on hard. The result followed the form book — Daniil Medvedev came in ranked #8, defending last year's round of 32. Daniil Medvedev extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-02-02 | Atp Cup | RR | hard | Daniil Medvedev | 6-2 6-4 |
| 2019-04-22 | Barcelona | SF | clay | Daniil Medvedev | 6-4 3-6 7-5 |
| 2018-12-31 | Brisbane | F | hard | Kei Nishikori | 6-4 3-6 6-2 |
| 2018-04-16 | Monte Carlo Masters | R32 | clay | Kei Nishikori | 7-5 6-2 |
Averages from each player's recent completed matches (19 vs 20). ATP, WTA & Challenger.