Matthew Ebden defeated John Isner 6-4 3-6 6-3 6-3 in the Australian Open round of 128 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 5–0, defending last year's round of 64. Matthew Ebden claimed a first win over John Isner in six meetings, narrowing the head-to-head to 5–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-07-15 | Newport | QF | grass | John Isner | 4-6 6-3 6-4 |
| 2018-07-23 | Atlanta | SF | hard | John Isner | 6-4 6-7(6) 6-1 |
| 2017-07-17 | Newport | F | grass | John Isner | 6-3 7-6(4) |
| 2015-06-29 | Wimbledon | R64 | grass | John Isner | 6-2 7-6(8) 6-4 |
| 2012-03-08 | Indian Wells Masters | R16 | hard | John Isner | 6-4 7-5 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (139 vs 200). ATP, WTA & Challenger.