John Isner defeated David Ferrer 7-6 7-6 in the Paris Masters round of 32 on hard. The upset overturned the form book — David Ferrer came in leading the head-to-head 7–1, defending last year's semi-final. John Isner narrowed the head-to-head to 7–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-01-18 | Australian Open | R16 | hard | David Ferrer | 6-4 6-4 7-5 |
| 2015-11-02 | Paris Masters | QF | hard | David Ferrer | 6-3 6-7(6) 6-2 |
| 2014-05-04 | Madrid Masters | R16 | clay | David Ferrer | 6-4 6-4 |
| 2012-09-14 | Davis Cup WG SF: ESP vs USA | RR | clay | David Ferrer | 6-7(3) 6-3 6-4 6-2 |
| 2011-11-07 | Paris Masters | QF | hard | John Isner | 6-3 3-6 6-3 |
| 2009-03-25 | Miami Masters | R64 | hard | David Ferrer | 6-3 3-6 6-2 |
| 2007-08-19 | New Haven | R32 | hard | David Ferrer | 6-7(2) 6-2 6-2 |
| 2007-08-13 | Cincinnati Masters | R64 | hard | David Ferrer | 7-6(3) 6-3 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 147). ATP, WTA & Challenger.