David Ferrer defeated John Isner 6-4 6-4 in the Madrid Masters round of 16 on clay. The result followed the form book — David Ferrer came in leading the head-to-head 6–2, defending last year's quarter-final. David Ferrer extended the head-to-head to 7–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-10-31 | Paris Masters | R32 | hard | John Isner | 7-6(4) 7-6(4) |
| 2016-01-18 | Australian Open | R16 | hard | David Ferrer | 6-4 6-4 7-5 |
| 2015-11-02 | Paris Masters | QF | hard | David Ferrer | 6-3 6-7(6) 6-2 |
| 2012-09-14 | Davis Cup WG SF: ESP vs USA | RR | clay | David Ferrer | 6-7(3) 6-3 6-4 6-2 |
| 2011-11-07 | Paris Masters | QF | hard | John Isner | 6-3 3-6 6-3 |
| 2009-03-25 | Miami Masters | R64 | hard | David Ferrer | 6-3 3-6 6-2 |
| 2007-08-19 | New Haven | R32 | hard | David Ferrer | 6-7(2) 6-2 6-2 |
| 2007-08-13 | Cincinnati Masters | R64 | hard | David Ferrer | 7-6(3) 6-3 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.