John Isner defeated Nick Kyrgios 7-5 6-3 in the Canada Masters round of 16 on hard. The upset overturned the form book — Nick Kyrgios came in leading the head-to-head 3–1, defending last year's round of 32, but John Isner had been the form player, winning 2 of their last 6 on hard. John Isner narrowed the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-02-25 | Acapulco | SF | hard | Nick Kyrgios | 7-5 5-7 7-6(7) |
| 2017-04-07 | Davis Cup WG QF: AUS vs USA | RR | hard | Nick Kyrgios | 7-5 7-6(5) 7-6(5) |
| 2016-08-01 | Atlanta | F | hard | Nick Kyrgios | 7-6(3) 7-6(4) |
| 2015-05-03 | Madrid Masters | R16 | clay | John Isner | 6-3 6-7(7) 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About