John Isner defeated Nick Kyrgios 6-3 6-7 6-4 in the Madrid Masters round of 16 on clay. The upset overturned the form book — Nick Kyrgios came in leading the head-to-head 3–1. John Isner narrowed the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-02-25 | Acapulco | SF | hard | Nick Kyrgios | 7-5 5-7 7-6 |
| 2017-04-07 | Davis Cup WG QF: AUS vs USA | RR | hard | Nick Kyrgios | 7-5 7-6 7-6 |
| 2016-08-01 | Atlanta | F | hard | Nick Kyrgios | 7-6 7-6 |
| 2015-08-10 | Canada Masters | R16 | hard | John Isner | 7-5 6-3 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About