John Isner defeated Roberto Bautista Agut 6-2 6-7 6-4 in the Beijing round of 16 on hard. The result followed the form book — John Isner came in leading the head-to-head 3–2. John Isner extended the head-to-head to 4–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-05-03 | Madrid Masters | R32 | clay | John Isner | 6-4 6-7(4) 7-6(6) |
| 2021-03-22 | Miami Masters | R16 | hard | Roberto Bautista Agut | 6-3 4-6 7-6(7) |
| 2019-03-18 | Miami Masters | QF | hard | John Isner | 7-6(1) 7-6(5) |
| 2016-01-11 | Auckland | QF | hard | Roberto Bautista Agut | 7-5 2-6 6-3 |
| 2014-01-06 | Auckland | SF | hard | John Isner | 3-6 7-6(2) 6-4 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.