Vasek Pospisil defeated John Isner 5-7 7-6 7-6 in the Canada Masters round of 64 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 5–1, defending last year's semi-final. Vasek Pospisil narrowed the head-to-head to 5–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-02-07 | Dallas | QF | hard | John Isner | 6-4 6-4 |
| 2017-07-24 | Atlanta | R16 | hard | John Isner | 6-3 6-4 |
| 2015-08-10 | Canada Masters | R32 | hard | John Isner | 7-6(1) 4-6 6-3 |
| 2015-08-03 | Washington | R16 | hard | John Isner | 6-4 7-6(6) |
| 2013-02-11 | San Jose | R16 | hard | John Isner | 7-6(3) 2-6 6-3 |
| 2011-10-31 | Valencia | R32 | hard | Vasek Pospisil | 6-3 3-6 7-6(9) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About