Jo-Wilfried Tsonga defeated John Isner 3-6 7-6 7-6 in the Paris Masters semi-final on hard. The upset overturned the form book — John Isner came in leading the head-to-head 3–1, defending last year's round of 32. Jo-Wilfried Tsonga narrowed the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-06-27 | Wimbledon | R32 | grass | Jo-Wilfried Tsonga | 6-7(3) 3-6 7-6(5) 6-2 19-17 |
| 2012-08-19 | Winston-Salem | SF | hard | John Isner | 6-4 3-6 7-6(3) |
| 2012-04-06 | Davis Cup WG QF: FRA vs USA | RR | clay | John Isner | 6-3 7-6(4) 5-7 6-3 |
| 2009-08-02 | Washington | R32 | hard | John Isner | 4-6 7-6(2) 7-6(4) |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.