John Isner defeated Gilles Simon 7-6 3-6 7-6 7-6 in the US Open round of 16 on hard. The result followed the form book — John Isner came in leading the head-to-head 2–0, defending last year's round of 32. John Isner extended the head-to-head to 3–0.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2012-04-06 | Davis Cup WG QF: FRA vs USA | RR | clay | John Isner | 6-3 6-2 7-5 |
| 2012-03-08 | Indian Wells Masters | QF | hard | John Isner | 6-3 1-6 7-5 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.