Andreas Seppi defeated Jurgen Melzer 6-2 6-0 in the Monte Carlo Masters round of 64 on clay. The upset overturned the form book — Jurgen Melzer came in leading the head-to-head 4–2. Andreas Seppi narrowed the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2012-01-30 | Zagreb | R16 | hard | Jurgen Melzer | 6-2 6-3 |
| 2011-02-14 | Marseille | R16 | hard | Jurgen Melzer | 7-5 6-3 |
| 2010-07-26 | Umag | QF | clay | Andreas Seppi | 6-1 6-4 |
| 2010-07-19 | Hamburg | SF | clay | Jurgen Melzer | 6-4 6-2 |
| 2010-02-08 | Rotterdam | R16 | hard | Jurgen Melzer | 6-2 6-2 |
| 2007-09-10 | Bucharest | R32 | clay | Andreas Seppi | 4-6 7-5 6-4 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.