Amelie Mauresmo defeated Serena Williams 6-4 0-6 6-2 in the US Open round of 16 on hard. The upset overturned the form book — Serena Williams came in leading the head-to-head 10–1, defending last year's round of 16, but Amelie Mauresmo had been the form player, winning 4 of their last 6 on hard. Amelie Mauresmo narrowed the head-to-head to 10–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2008-06-23 | Wimbledon | R32 | grass | Serena Williams | 7-6(5) 6-1 |
| 2005-01-17 | Australian Open | QF | hard | Serena Williams | 6-2 6-2 |
| 2004-11-10 | WTA Tour Championships | SF | carpet | Serena Williams | 4-6 7-6(2) 6-4 |
| 2004-06-21 | Wimbledon | SF | grass | Serena Williams | 6-7(4) 7-5 6-4 |
| 2003-05-26 | Roland Garros | QF | clay | Serena Williams | 6-1 6-2 |
| 2003-05-12 | Rome | SF | clay | Amelie Mauresmo | 1-6 7-5 6-3 |
| 2003-02-03 | Paris | F | carpet | Serena Williams | 6-3 6-2 |
| 2002-06-24 | Wimbledon | SF | grass | Serena Williams | 6-2 6-1 |
| 2002-01-06 | Sydney | QF | hard | Serena Williams | 6-4 7-6(6) |
| 2000-02-14 | Hanover | SF | carpet | Serena Williams | 6-2 6-7(4) 7-6(3) |
| 1999-02-22 | Paris | F | carpet | Serena Williams | 6-2 3-6 7-6 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (169 vs 199). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About