Serena Williams defeated Amelie Mauresmo 4-6 7-6 6-4 in the WTA Tour Championships semi-final on carpet. The result followed the form book — Serena Williams came in leading the head-to-head 9–2. Serena Williams extended the head-to-head to 10–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2008-06-23 | Wimbledon | R32 | grass | Serena Williams | 7-6(5) 6-1 |
| 2006-08-28 | US Open | R16 | hard | Amelie Mauresmo | 6-4 0-6 6-2 |
| 2005-01-17 | Australian Open | QF | hard | Serena Williams | 6-2 6-2 |
| 2004-06-21 | Wimbledon | SF | grass | Serena Williams | 6-7(4) 7-5 6-4 |
| 2003-05-26 | Roland Garros | QF | clay | Serena Williams | 6-1 6-2 |
| 2003-05-12 | Rome | SF | clay | Amelie Mauresmo | 1-6 7-5 6-3 |
| 2003-02-03 | Paris | F | carpet | Serena Williams | 6-3 6-2 |
| 2002-06-24 | Wimbledon | SF | grass | Serena Williams | 6-2 6-1 |
| 2002-01-06 | Sydney | QF | hard | Serena Williams | 6-4 7-6(6) |
| 2000-02-14 | Hanover | SF | carpet | Serena Williams | 6-2 6-7(4) 7-6(3) |
| 1999-02-22 | Paris | F | carpet | Serena Williams | 6-2 3-6 7-6 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.