Andreas Seppi defeated Vasek Pospisil 3-6 6-2 7-5 in the Us Open qualifying round 2 on hard. Andreas Seppi extended the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-09-30 | Beijing | Q1 | hard | Vasek Pospisil | 6-3 6-4 |
| 2016-05-09 | Rome Masters | R64 | clay | Andreas Seppi | 7-6(5) 7-6(2) |
| 2015-01-11 | Sydney | R32 | hard | Vasek Pospisil | 6-3 7-6(4) |
| 2013-04-05 | Davis Cup WG QF: CAN vs ITA | RR | hard | Andreas Seppi | 5-7 4-6 6-4 6-3 6-3 |
| 2012-08-06 | Canada Masters | R64 | hard | Vasek Pospisil | 4-6 6-4 7-6(6) |
| 2011-10-24 | St. Petersburg | R32 | carpet | Andreas Seppi | 7-5 7-6(4) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (33 vs 111). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About