Jannik Sinner defeated John Isner 6-4 7-6 6-3 in the Wimbledon round of 32 on grass. The result followed the form book — Jannik Sinner came in leading the head-to-head 2–1, defending last year's round of 128. Jannik Sinner extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-06-27 | Wimbledon | R32 | grass | Jannik Sinner | 6-4 7-6 6-3 |
| 2021-11-26 | Davis Cup Finals RR: USA vs ITA | RR | hard | Jannik Sinner | 6-2 6-0 |
| 2021-08-16 | Cincinnati Masters | R32 | hard | John Isner | 5-7 7-6 6-4 |
Averages over each player's completed matches in the selected window (200 vs 64). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About