Salvatore Caruso defeated Ernesto Escobedo 3-6 6-4 6-3 6-4 in the US Open round of 64 on hard. The result followed the form book — Salvatore Caruso came in leading the head-to-head 1–0. Salvatore Caruso extended the head-to-head to 2–0.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-09-25 | San Diego | Q16 | hard | Salvatore Caruso | 7-5 1-6 6-4 |