John Isner defeated Mischa Zverev 6-3 7-6 in the Acapulco round of 32 on hard. John Isner extended the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-07-23 | Atlanta | QF | hard | John Isner | 7-5 4-6 6-1 |
| 2017-08-28 | US Open | R32 | hard | Mischa Zverev | 6-4 6-3 7-6(5) |
| 2017-05-22 | Geneva | R16 | clay | Mischa Zverev | 6-4 6-7(5) 6-3 |
| 2017-01-16 | Australian Open | R64 | hard | Mischa Zverev | 6-7(4) 6-7(4) 6-4 7-6(7) 9-7 |
| 2016-10-31 | Paris Masters | R64 | hard | John Isner | 7-6(8) 6-4 |
| 2009-09-28 | Bangkok | R16 | hard | John Isner | 7-6(5) 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (118 vs 40). ATP, WTA & Challenger.