John Millman defeated Reilly Opelka 6-3 7-6 in the Tokyo semi-final on hard. The result followed the form book — John Millman came in leading the head-to-head 2–1. John Millman extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-02-14 | Delray Beach | SF | hard | Reilly Opelka | 7-6(8) 6-7(3) 7-6(4) |
| 2021-08-02 | Washington | R16 | hard | John Millman | 6-3 7-6(4) |
| 2021-06-14 | Queen's Club | R32 | grass | John Millman | 7-6(4) 5-7 7-6(6) |
Averages from each player's recent completed matches (20 vs 19). ATP, WTA & Challenger.