
Lucas Pouille defeated Karen Khachanov 6-7 6-4 6-2 in the Cincinnati Masters round of 16 on hard. The upset overturned the form book — Karen Khachanov came in ranked #15, leading the head-to-head 3–2, defending last year's round of 16. Lucas Pouille narrowed the head-to-head to 3–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-05-02 | Madrid Masters | R64 | clay | Lucas Pouille | 6-3 6-4 |
| 2021-06-21 | Mallorca | R32 | grass | Karen Khachanov | 7-6(7) 3-6 6-4 |
| 2018-05-28 | Roland Garros | R32 | clay | Karen Khachanov | 6-3 7-5 6-3 |
| 2018-02-26 | Dubai | R16 | hard | Lucas Pouille | 6-4 3-6 6-3 |
| 2018-02-19 | Marseille | F | hard | Karen Khachanov | 7-5 3-6 7-5 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.