Bethanie Mattek Sands defeated Venus Williams 6-7 6-3 6-1 in the San Jose round of 32 on hard. The upset overturned the form book — Venus Williams came in leading the head-to-head 4–0, defending last year's quarter-final, but Bethanie Mattek Sands had been the form player, winning 1 of their last 7 on hard. Bethanie Mattek Sands claimed a first win over Venus Williams in five meetings, narrowing the head-to-head to 4–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2012-08-27 | US Open | R128 | hard | Venus Williams | 6-3 6-1 |
| 2009-08-31 | US Open | R64 | hard | Venus Williams | 6-4 6-2 |
| 2009-05-25 | Roland Garros | R128 | clay | Venus Williams | 6-1 4-6 6-2 |
| 2006-06-26 | Wimbledon | R128 | grass | Venus Williams | 6-1 6-0 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (40 vs 77). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About