Kevin Anderson defeated Frances Tiafoe 6-3 3-6 6-2 in the Tokyo round of 16 on hard. The result followed the form book — Kevin Anderson came in leading the head-to-head 3–1, defending last year's round of 16. Kevin Anderson extended the head-to-head to 4–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-04-26 | Estoril | R32 | clay | Kevin Anderson | 4-6 7-6(6) 7-6(4) |
| 2019-01-14 | Australian Open | R64 | hard | Frances Tiafoe | 4-6 6-4 6-4 7-5 |
| 2018-03-19 | Miami Masters | R16 | hard | Kevin Anderson | 7-6(3) 6-4 |
| 2018-02-12 | New York | QF | hard | Kevin Anderson | 6-3 5-7 6-4 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.