Daniil Medvedev defeated Joao Sousa 6-4 6-1 in the St. Petersburg round of 32 on carpet. Daniil Medvedev extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-04-15 | Monte Carlo Masters | R64 | clay | Daniil Medvedev | 6-1 6-1 |
| 2018-04-30 | Estoril | R32 | clay | Joao Sousa | 7-6(1) 7-5 |
Averages from each player's recent completed matches (19 vs 20). ATP, WTA & Challenger.