Andreas Seppi defeated Joao Sousa 7-5 6-4 in the Winston-Salem round of 64 on hard. The upset overturned the form book — Joao Sousa came in leading the head-to-head 3–2, defending last year's round of 32. Andreas Seppi narrowed the head-to-head to 3–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-06-28 | Wimbledon | R128 | grass | Andreas Seppi | 4-6 6-4 7-5 6-2 |
| 2020-10-19 | Antwerp | Q1 | hard | Joao Sousa | 6-4 2-6 6-4 |
| 2018-02-12 | Rotterdam | R32 | hard | Andreas Seppi | 6-4 1-6 6-2 |
| 2016-10-31 | Paris Masters | R64 | hard | Joao Sousa | 6-4 6-4 |
| 2015-07-20 | Umag | R16 | clay | Joao Sousa | 6-2 6-2 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.