Cameron Norrie defeated John Isner 7-6 6-4 in the Lyon quarter-final on clay. Cameron Norrie extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-05-02 | Madrid Masters | R32 | clay | Cameron Norrie | 6-4 6-7(5) 6-4 |
| 2022-02-21 | Acapulco | R16 | hard | Cameron Norrie | 6-7(2) 6-3 6-4 |
| 2021-08-16 | Cincinnati Masters | R64 | hard | John Isner | 4-6 7-6(5) 6-4 |
| 2018-10-22 | Vienna | R32 | hard | John Isner | 6-7(1) 6-4 7-6(7) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Per-surface Serve / Return Rating (0–100, percentile within the clay field, opponent-adjusted over 52 weeks). About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.