Leonardo Mayer defeated Fabio Fognini 6-3 6-4 in the Madrid Masters round of 64 on clay. The upset overturned the form book — Fabio Fognini came in leading the head-to-head 4–1, defending last year's round of 32, but Leonardo Mayer had been the form player, winning 2 of their last 6 on clay. Leonardo Mayer narrowed the head-to-head to 4–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-01-14 | Australian Open | R64 | hard | Fabio Fognini | 7-6(3) 6-3 7-6(5) |
| 2018-02-12 | Buenos Aires | R16 | clay | Leonardo Mayer | 6-3 6-3 |
| 2014-02-10 | Buenos Aires | R16 | clay | Fabio Fognini | 6-7(4) 6-3 6-2 |
| 2014-02-03 | Vina del Mar | F | clay | Fabio Fognini | 6-2 6-4 |
| 2013-07-08 | Stuttgart | R16 | grass | Fabio Fognini | 6-1 6-3 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.