John Isner defeated Juan Martin del Potro 6-1 7-6 in the Miami Masters semi-final on hard. The upset overturned the form book — Juan Martin del Potro came in leading the head-to-head 8–3, defending last year's round of 32. John Isner narrowed the head-to-head to 8–4.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-08-27 | US Open | QF | hard | Juan Martin del Potro | 6-7(5) 6-3 7-6(4) 6-2 |
| 2018-05-28 | Roland Garros | R16 | clay | Juan Martin del Potro | 6-4 6-4 6-4 |
| 2017-10-30 | Paris Masters | QF | hard | John Isner | 6-4 6-7(5) 6-4 |
| 2017-08-07 | Canada Masters | R64 | hard | Juan Martin del Potro | 7-5 7-5 |
| 2016-10-17 | Stockholm | R32 | hard | Juan Martin del Potro | 6-4 7-6(6) |
| 2016-06-13 | Queen's Club | R32 | grass | John Isner | 7-6(2) 6-4 |
| 2013-08-11 | Cincinnati Masters | SF | hard | John Isner | 6-7(5) 7-6(9) 6-3 |
| 2013-07-29 | Washington | F | hard | Juan Martin del Potro | 3-6 6-1 6-2 |
| 2011-02-14 | Memphis | R32 | hard | Juan Martin del Potro | 6-4 6-3 |
| 2009-03-12 | Indian Wells Masters | R16 | hard | Juan Martin del Potro | 7-6(4) 7-6(3) |
| 2008-08-10 | Washington | QF | hard | Juan Martin del Potro | 6-4 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 72). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About