Philipp Kohlschreiber defeated John Isner 7-6 6-4 in the Vienna round of 32 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 4–3, defending last year's quarter-final. Philipp Kohlschreiber narrowed the head-to-head to 4–4.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2014-08-25 | US Open | R32 | hard | Philipp Kohlschreiber | 7-6(4) 4-6 7-6(2) 7-6(4) |
| 2014-01-06 | Auckland | QF | hard | John Isner | 6-7(4) 7-6(4) 7-6(5) |
| 2013-08-26 | US Open | R32 | hard | Philipp Kohlschreiber | 6-4 3-6 7-5 7-6(5) |
| 2012-08-27 | US Open | R32 | hard | Philipp Kohlschreiber | 6-4 3-6 4-6 6-3 6-4 |
| 2012-08-06 | Canada Masters | R16 | hard | John Isner | 6-7(3) 6-4 6-4 |
| 2012-05-13 | Rome Masters | R64 | clay | John Isner | 2-6 7-6(3) 6-2 |
| 2010-10-04 | Beijing | R16 | hard | John Isner | 7-6(3) 3-6 6-3 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.