John Isner defeated Yoshihito Nishioka 4-6 6-3 6-4 in the Memphis round of 16 on hard. The upset overturned the form book — Yoshihito Nishioka came in defending last year's quarter-final, but John Isner had been the form player, winning 2 of their last 6 on hard. John Isner extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-10-04 | Indian Wells Masters | R64 | hard | John Isner | 6-3 6-4 |
| 2021-06-28 | Wimbledon | R128 | grass | Yoshihito Nishioka | 7-6(5) 2-6 6-3 6-7(3) 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 197). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About