Rafael Nadal defeated Andreas Seppi 6-0 7-5 6-1 in the US Open round of 64 on hard. The result followed the form book — Rafael Nadal came in leading the head-to-head 7–1, defending last year's round of 32. Rafael Nadal extended the head-to-head to 8–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-08-08 | Rio Olympics | R32 | hard | Rafael Nadal | 6-3 6-3 |
| 2015-07-27 | Hamburg | SF | clay | Rafael Nadal | 6-1 6-2 |
| 2014-04-13 | Monte Carlo Masters | R16 | clay | Rafael Nadal | 6-1 6-3 |
| 2009-08-16 | Cincinnati Masters | R32 | hard | Rafael Nadal | 7-6(4) 7-6(3) |
| 2009-04-27 | Rome Masters | R32 | clay | Rafael Nadal | 6-2 6-3 |
| 2008-02-18 | Rotterdam | R16 | hard | Andreas Seppi | 3-6 6-3 6-4 |
| 2006-09-22 | Davis Cup WG PO: ESP vs ITA | RR | clay | Rafael Nadal | 6-0 6-4 6-3 |
| 2005-09-23 | Davis Cup WG PO: ITA vs ESP | RR | clay | Rafael Nadal | 6-1 6-2 5-7 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.