Gilles Muller defeated John Isner 3-6 7-6 7-6 in the London round of 16 on carpet. The upset overturned the form book — John Isner came in leading the head-to-head 4–2, defending last year's quarter-final. Gilles Muller narrowed the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2017-07-24 | Atlanta | SF | hard | John Isner | 6-4 6-2 |
| 2016-06-13 | Queen's Club | R16 | grass | Gilles Muller | 3-6 7-6 7-6 |
| 2015-01-19 | Australian Open | R32 | hard | Gilles Muller | 7-6 7-6 6-4 |
| 2012-02-20 | Memphis | R32 | hard | John Isner | 7-6 7-6 |
| 2011-07-18 | Atlanta | SF | hard | John Isner | 7-5 6-7 6-1 |
| 2010-07-19 | Atlanta | R16 | hard | John Isner | 4-6 7-6 7-6 |
Averages over each player's completed matches in the selected window (139 vs 200). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About