John Isner defeated Andreas Seppi 7-6 6-4 in the Indian Wells Masters round of 64 on hard. The result followed the form book — John Isner came in leading the head-to-head 2–1, defending last year's round of 16. John Isner extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2015-05-24 | Roland Garros | R128 | clay | John Isner | 7-5 6-2 6-3 |
| 2012-05-13 | Rome Masters | R32 | clay | Andreas Seppi | 2-6 7-6(5) 7-5 |
| 2010-01-18 | Australian Open | R128 | hard | John Isner | 6-3 6-3 3-6 5-7 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.