John Isner defeated Mikhail Youzhny 6-3 6-4 6-4 in the US Open round of 64 on hard. The upset overturned the form book — Mikhail Youzhny came in leading the head-to-head 2–1, defending last year's round of 128. John Isner narrowed the head-to-head to 2–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-03-19 | Miami Masters | R32 | hard | John Isner | 6-4 6-3 |
| 2010-08-30 | US Open | R32 | hard | Mikhail Youzhny | 6-4 6-7(7) 7-6(5) 6-4 |
| 2009-08-10 | Canada Masters | R32 | hard | Mikhail Youzhny | 6-7(8) 6-1 6-3 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About