John Isner defeated Feliciano Lopez 7-6 6-7 7-6 in the Queen's Club round of 16 on grass. The result followed the form book — John Isner came in leading the head-to-head 4–3. John Isner extended the head-to-head to 5–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-10-24 | Vienna | R16 | hard | John Isner | 7-6(1) 3-6 7-6(2) |
| 2016-01-18 | Australian Open | R32 | hard | John Isner | 6-7(8) 7-6(5) 6-2 6-4 |
| 2014-10-05 | Shanghai Masters | R16 | hard | Feliciano Lopez | 6-3 6-4 |
| 2014-06-23 | Wimbledon | R32 | grass | Feliciano Lopez | 6-7(8) 7-6(6) 7-6(3) 7-5 |
| 2012-04-09 | Houston | SF | clay | John Isner | 6-7(5) 7-6(4) 6-3 |
| 2012-01-16 | Australian Open | R32 | hard | Feliciano Lopez | 6-3 6-7(3) 6-4 6-7(0) 6-1 |
| 2011-11-07 | Paris Masters | R16 | hard | John Isner | 6-4 6-2 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.