Dominic Thiem defeated John Isner 7-6 6-3 in the Nice semi-final on clay. The result followed the form book — Dominic Thiem came in leading the head-to-head 2–1, defending last year's round of 16. Dominic Thiem extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-05-03 | Madrid Masters | QF | clay | Dominic Thiem | 3-6 6-3 6-4 |
| 2017-09-22 | Laver Cup | RR | hard | Dominic Thiem | 6-7(15) 7-6(2) [10-7] |
| 2015-10-05 | Beijing | R32 | hard | John Isner | 7-5 6-1 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.