Leonardo Mayer defeated Feliciano Lopez 7-6 7-6 in the Madrid Masters round of 32 on clay. The upset overturned the form book — Feliciano Lopez came in leading the head-to-head 2–0, defending last year's quarter-final. Leonardo Mayer claimed a first win over Feliciano Lopez in three meetings, narrowing the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-05-02 | Madrid Masters | R64 | clay | Feliciano Lopez | 7-6(5) 4-6 6-4 |
| 2012-01-16 | Australian Open | R128 | hard | Feliciano Lopez | 7-6(5) 6-3 7-6(2) |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.