John Isner defeated Adrian Mannarino 7-6 6-4 in the Madrid Masters round of 64 on clay. The result followed the form book — John Isner came in leading the head-to-head 7–2, defending last year's round of 16. John Isner extended the head-to-head to 8–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2023-01-16 | Australian Open | R128 | hard | Adrian Mannarino | 6-7 7-6 6-2 6-2 |
| 2019-02-25 | Acapulco | R32 | hard | John Isner | 6-3 4-6 6-3 |
| 2019-02-18 | Delray Beach | QF | hard | John Isner | 7-6 6-4 |
| 2016-08-01 | Atlanta | R16 | hard | John Isner | 6-4 6-0 |
| 2016-03-07 | Indian Wells Masters | R32 | hard | John Isner | 6-4 7-6 |
| 2015-10-11 | Shanghai Masters | R64 | hard | John Isner | 6-1 6-2 |
| 2013-07-08 | Newport | R16 | grass | John Isner | 6-0 7-6 |
| 2013-06-24 | Wimbledon | R64 | grass | Adrian Mannarino | 1-1 |
| 2010-10-25 | Montpellier | R16 | hard | John Isner | 7-6 6-7 6-3 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Mannarino A.: 13 days rest · 2 matches (14d). Higher means fresher. About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About