Rafael Nadal defeated John Isner 7-6 4-6 6-3 in the Monte Carlo Masters round of 16 on clay. The result followed the form book — Rafael Nadal came in leading the head-to-head 7–1, defending last year's quarter-final. Rafael Nadal extended the head-to-head to 8–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-05-09 | Rome Masters | R32 | clay | Rafael Nadal | 6-3 6-1 |
| 2017-10-02 | Beijing | QF | hard | Rafael Nadal | 6-4 7-6 |
| 2017-09-22 | Laver Cup | RR | hard | John Isner | 7-5 7-6 |
| 2015-05-10 | Rome Masters | R16 | clay | Rafael Nadal | 6-4 6-4 |
| 2013-08-11 | Cincinnati Masters | F | hard | Rafael Nadal | 7-6 7-6 |
| 2011-05-22 | Roland Garros | R128 | clay | Rafael Nadal | 6-4 6-7 6-7 6-2 6-4 |
| 2010-05-09 | Madrid Masters | R16 | clay | Rafael Nadal | 7-5 6-4 |
| 2010-03-11 | Indian Wells Masters | R16 | hard | Rafael Nadal | 7-5 3-6 6-3 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About