Denis Istomin defeated Guillermo Garcia Lopez 6-2 7-5 in the Eastbourne round of 16 on grass. The upset overturned the form book — Guillermo Garcia Lopez came in leading the head-to-head 4–1. Denis Istomin narrowed the head-to-head to 4–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2020-02-17 | Delray Beach | Q1 | hard | Denis Istomin | 7-5 6-2 |
| 2015-02-09 | Rotterdam | R32 | hard | Guillermo Garcia Lopez | 7-6(5) 6-4 |
| 2013-09-16 | St. Petersburg | QF | carpet | Guillermo Garcia Lopez | 6-2 6-4 |
| 2011-04-18 | Barcelona | R64 | clay | Guillermo Garcia Lopez | 7-6(6) 6-3 |
| 2010-06-13 | Eastbourne | SF | grass | Guillermo Garcia Lopez | 3-6 6-3 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About