Mikhail Youzhny defeated Lleyton Hewitt 6-3 3-6 6-7 6-4 7-5 in the US Open round of 16 on hard. The upset overturned the form book — Lleyton Hewitt came in leading the head-to-head 5–1, defending last year's round of 32. Mikhail Youzhny narrowed the head-to-head to 5–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2012-08-12 | Cincinnati Masters | R64 | hard | Lleyton Hewitt | 6-4 6-4 |
| 2010-04-25 | Rome Masters | R64 | clay | Lleyton Hewitt | 6-4 4-6 6-3 |
| 2009-10-05 | Tokyo | SF | hard | Mikhail Youzhny | 6-2 5-7 7-5 |
| 2008-03-13 | Indian Wells Masters | R32 | hard | Lleyton Hewitt | 7-5 6-1 |
| 2002-06-24 | Wimbledon | R16 | grass | Lleyton Hewitt | 6-3 6-3 7-5 |
| 2002-06-17 | s Hertogenbosch | R16 | grass | Lleyton Hewitt | 6-4 5-7 7-6(4) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 85). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About