Denis Istomin defeated John Isner 5-7 7-6 6-3 in the Rome Masters round of 64 on clay. Denis Istomin extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2013-02-18 | Memphis | R32 | hard | Denis Istomin | 6-4 6-3 |
| 2009-07-19 | Indianapolis | R16 | hard | John Isner | 6-4 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About