John Isner defeated Xavier Malisse 7-6 6-2 in the San Jose quarter-final on hard. The upset overturned the form book — Xavier Malisse came in defending last year's round of 32, but John Isner had been the form player, winning 2 of their last 5 on hard. John Isner extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2012-08-27 | US Open | R128 | hard | John Isner | 6-3 7-6(5) 5-7 7-6(9) |
| 2012-05-20 | Nice | R16 | clay | John Isner | 7-6(3) 7-6(5) |
| 2010-08-01 | Washington | R16 | hard | Xavier Malisse | 6-4 3-6 7-6(5) |
| 2010-04-05 | Houston | R16 | clay | Xavier Malisse | 7-6(3) 6-7(7) 7-6(3) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 31). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About